Lily Goodwill, the vamp with a heart of gold, gets a disturbing call on the Suicide Prevention Hotline. A hysterical caller is convinced a werewolf is breaking into his house. Lily dispatches the appropriate services, convinced that "someone is off their meds." Oh, that it were true.
Her best friends and housemates - vampires, a demon and a hell hound - rally to her side as the odds stack up against her. A conniving vampire Queen, a witch bent on seduction and a determined assassin with a contract on Lily's undead life round out a season in the City by the Bay.